Aspirin alone without the long chain essential fatty acids, will not produce maximum health benefits. Dietary arachidonic acid is usually ample in the modern American diet, but dietary supplementation with EPA and docosahexaenoic acid (DHA), the principal essential omega-3 fatty acids in fish, cod liver, krill oils, and animal fats, in a low-carbohydrate or ketogenic diet are required for aspirin to do its work.