We’ve discussed Metformin a number of times before, so the news from this latest research caught my eye:
long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic. Treatment with metformin mimics some of the benefits of calorie restriction, such as improved physical performance, increased insulin sensitivity, and reduced low-density lipoprotein and cholesterol levels without a decrease in caloric intake.
This isn’t the first time researchers have witnessed such beneficial effects, but the challenge is, of course, in understanding what significance this recent mouse study has for humans.
- Metformin improves healthspan and lifespan in mice, Martin-Montalvo, Mercken, et al. Nature Communications. 4, Article number: 2192 doi:10.1038/ncomms3192, 30 July 2013
- Pill linked to long life in mice, Helen Briggs, BBC News, 30 July, 2013.