Dr. Robert Lustig – The Skinny on Obesity – Episode 4

In this the fourth episode of the series, Dr. Lustig looks at sugar’s effects on brain chemistry, specifically, how our reward system (mediated by dopamine in the nucleus accumbens) is changed in response to chronic overconsumption of sugar.

Specifically, Lustig asserts that sugar downregulates the same dopamine system in the nucleus accumbens (reward center of the brain) that drugs like cocaine do. In this sense, an addiction marked by domamine resistence in the pleasure center is an additional driver of obesity in addition to the leptin and insulin resistence he described in previous videos. All, of course, are the result of sugar consumption



Dr. Donald W. Miller – Enjoy Eating Saturated Fats: They’re Good For You

Dr. Miller, professor of cardiothoracic surgery at the University of Washington, gives a nifty talk in which he frames the historical context for our mistaken fear of saturated fats and tries to expose the real science that should inform our consumption decisions.

Really a worthwhile video to watch if you’re concerned about “all the fat” you’re eating on a low carb ketogenic diet.


Dr. Robert Lustig – The Skinny on Obesity – Episode 3

In the third installment of Dr. Robert Lustig’s, The Skinny On Obesity series, Dr. Lustig covers how our consumption of carbohydrate rich diets influence the roles of insulin and leptin hormones in our bodies, and how these contribute to obesity.

This directly addresses the misleading (and dangerous) notion that “a calorie is a calorie.” It turns (and this is no surprise to anyone who pays attention to nutrition research, really) out that different types of calories trigger different responses in the body’s hormonal response.


Dr. Eric Westman – Duke University New Atkins Ketogenic Diet for Weight Loss

Looks like Dr. Westman put together a video covering his intro at his clinic.  It’s a great resource if you are contemplating a low carb/ketogenic diet, or you have someone in your life who wants to know more about it, is suspicious about it and thinks its a crackpot, non-scientific approach. Dr. Westman is a respected physician working at a respected medical university.

Funny how people have an easier time believing the crackpot on TV than someone like this.



What’s So Bad About Fructose?

Lots of people write about fructose. From Lustig to Sisson and just about everyone in between. Currently, I’m reading Robb Wolf’s, “The Paleo Solution“, and was quite taken by this little quote that summarizes some of the problems with our infamous little sweetener:

Fructose preferentially fills liver glycogen. That means fructose accelerates the process described above in which liver function is destroyed due to carbohydrate overfeeding. This happens directly because the liver is the only tissue that can handle fructose, but it also happens indirectly because eating fructose increases the amount of glucose the liver absorbs. Fructose up-regulates the glucose transport molecules in the liver, making the liver “hungry” for sugar. This leads to increased Palmitic Acid production, which leads to leptin resistance. Oh, yeah, since we were talking about AGEs, fructose is seven times more reactive than glucose in forming AGEs…

So let’s recap. Fructose:
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