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Aspirin: A Unique Remedy

Abstract

In the course of research into the biochemistry and physiology of the endpoints of essential fatty acid metabolism known as eicosanoids, the mechanism by which aspirin exerts its analgesic effect was revealed. It is now known that aspirin does not prevent the COX enzyme from converting arachidonic acid to pain-producing proinflammatory eicosanoids as had long been assumed, but rather it modifies the COX enzyme by acetylating it thereby making it convert arachidonic acid to antiinflammatory eicosanoids. During these same research activities, hitherto unknown classes of naturally occurring, anti-inflammatory, pro-healing eicosanoids known as lipoxins, resolvins, protectins, neuroprotectins, and maresins were discovered. Aspirin was found to multiply many times the healing power of these natural lipid mediators by creating aspirin-triggered counterparts to all.
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Ketosis, Ketone Bodies, And Ketoacidosis – An Excerpt From Modern Nutritional Diseases, 2nd Edition

The cover or Modern Nutritional Diseases by Frank and Alice Ottoboni
Cover of the 1st Edition of Modern Nutritional Diseases by Frank and Alice Ottoboni
The following text is excerpted from Lipids (Chapter 8) of Modern Nutritional Diseases, 2nd Edition.

Ketone Bodies and Ketosis: Ketones are organic chemicals in which an interior carbon in a molecule forms a double bond with an oxygen molecule. Acetone, a familiar chemical, is the smallest ketone possible. It is composed of three carbons, with the double bond to oxygen on the middle carbon. Biological ketone bodies include acetone, larger ketones, and biochemicals that can become ketones. The most important of the ketone bodies are hydroxybutyrate and acetoacetate, both of which are formed from condensation of two acetyl CoA molecules. Acetone is formed from a nonenzymatic decarboxylation of acetoacetate.
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Metabolic Pathways of Proteins, Carbohydrates and Fats in Humans

The next time someone tells you that carbohydrates are essential for life, or that you’ll die if you don’t eat carbohydrates, point them to the metabolic pathways diagram and ask them to identify which metabolic needs go unmet without carbohydrate ingestion.

Diagram of metabolic pathways for fats, carbohydrates and proteins.

See a full-size image of the metabolic pathways. Click terms in the image for additional details.

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Good News: 2nd Edition of Modern Nutritional Diseases is Being Readied for Printer

The cover or Modern Nutritional Diseases by Frank and Alice Ottoboni
Cover of the 1st Edition of Modern Nutritional Diseases by Frank and Alice Ottoboni

I’ve had the pleasure of corresponding with Fred Ottoboni recently and I have some good news to share: He and Alice are currently readying for print a second edition of Modern Nutritional Diseases.

Fred reports that the new edition will contain several new chapters, including:

  • Ch. 9 – Essential Fatty Acids and Eicosanoids
  • Ch 10 – The Diet-Disease Connection
  • Ch 11 – Prevention, the Shunned Science

Reportedly, the new version will dive deeper into the inflammation connection to many of the modern chronic diseases, more on Omega-3’s, and of course, the benefits of a low carbohydrate diet.
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Ketosis: Fear, Uncertainty and Doubt

Perhaps nothing is more damaging to the new low-carber than the intentional spread of fear, uncertainty and doubt regarding the state of ketosis compared to the dangerous state of ketoacidosis. The former is a natural and healthy state of existence, the latter is a condition that threatens the life of type 1 diabetics and type 2 diabetics whose disease has progressed to the point where their pancreatic beta cells can no longer produce insulin (ketoacidosis is also a risk for alcoholics). So if you’re not an alcoholic, a type 1 diabetic or a late-stage type 2 diabetic, fear of ketosis is misdirected.  You should regard with suspicion anyone who confuses the two and warns you against a low-carb diet because they cannot tell the difference.
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