A Sad Tale of Unintended Consequences

It all began in 1984 when the prestigious Noble Prize in Medicine was awarded for the revelation that the lowly drug Aspirin prevented the COX-2 enzyme from converting the biochemical arachidonic acid to pain-producing inflammatory end products. Bonanza!  Here was the...

Lowly Aspirin Versus NSAID Challengers

Introduction In 1982, the Nobel Prize in Medicine was granted jointly to Sune Bergstrom, Bengt Samuelsson, and Sir John Vane, which, in essence, explained the mechanism for the analgesic effect of aspirin. The Nobel Summary pointed out that prostaglandins and related...