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Research: Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways

We’ve been providing a fair bit of coverage on cancer recently, and today will be no exception.

Unfortunately, right now I can offer little more than a pointer to the research article (published in The Journal of Clinical Investigation). I’m still working my way through it and may not have the time to return. So if you’re interested in sharing your thoughts on it, please add to the comments below!
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Full Fat Goes Mainstream?

NPR’s Morning Edition aired a delightful segment on full fait dairy foods and the (to some) unexpected consequence: “people who eat higher fat dairy tend to be leaner than people who eat skim (low fat) products.” It turns out that this “high fat paradox” is present in children as well.

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Ketopia’s New Design

In January of 2012 I started Ketopia with a stock theme, an image across the top that spoke of my journey, and the intention to push the Content First philosophy to the extreme. A couple years and a few hundred posts later (by multiple contributors!), we have a true community, a unique visual identity and a new design for the website.
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Lustig, the EFSA, Fructose, and Poison

Just a quick note to point to Robert Lustig’s recent article in The Guardian: Fructose: The Poison Index.

It’s typical Lustig. Written on the occasion of The European Food and Safety Agency’s (EFSA) ruling that allows food processors and mongers to make health claims about the fructose content of their foods.

And yet the scientific data on fructose says it is one of the most egregious components of the western diet, directly contributing to heart disease and diabetes, and associated with cancer and dementia. Nature magazine has just published a scathing indictment of fructose by Dr Lewis Cantley, one of the US’s leading cancer researchers. But the EFSA says it sees no harm, justifying its stance on the basis that fructose has a lower glycaemic index than glucose.

Resources

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Robert Lustig’s ‘Fat Chance: Fructose 2.0′

Robert Lustig attempts to reprise his viral hit, Sugar the Bitter Truth with a new installment. This one borrows part of the title from his book: “Fat Chance: Fructose 2.0″.

As you might expect, it’s a pretty darn good view. Favorite quote? How ’bout this: “It’s never gluttony and sloth. It’s always biochemical. The question is, ‘Are you smart enough to figure out what the biochemistry is?’”

For those of you interested in Leptin, this is a must watch.

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The Changing Understanding of Fats

I consider myself to be as fortunate as I am frustrated to witness the current revolution in our understanding of the role of fats in proper nutrition and health. The tide seems to be turning and we’re returning from whence we came. Every week, it seems, someone else is questioning the “fat is bad” orthodoxy, and medical practitioners are speaking out.

This week it’s the British Medical Journal, and I have Alice and Fred Ottoboni to thank for pointing it out to me.

When they say, “This is important…”, I tend to listen.
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President Taft Lost 60lbs on Low Carb

Watching this story sourced from the Annals of Internal Medicine make the rounds on the newswires…

President William Howard Taft, the country’s heaviest commander in chief and a high-profile yo-yo dieter in his day, lost 60 pounds in the early 1900s on a low-carb diet with the help of a diet doctor. (source)

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Gary Taubes Describes First NuSi Experiment

Gary Taubes, author of Good Calories, Bad Calories and his reprise for lay people, Why We Get Fat, reveals in the September issue of Scientific American the research agenda for NuSi:

[...] Because the ultimate goal is to identify the environmental triggers of obesity, experiments should, ideally, be directed at elucidating the processes that lead to the accumulation of excess fat. But obesity can take decades to develop, so any month-to-month fat gains may be too small to detect. Thus, the first step that NuSI-funded researchers will take is to test the competing hypotheses on weight loss, which can happen relatively quickly. These first results will then help determine what future experiments are needed to further clarify the mechanisms at work and which of these hypotheses is correct.

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