“A 3-Year-Old Mute Girl Miraculously Starts Talking After Cream Cheese Diet.” This headline appeared in the news for several days in July, 2013 (1). It is a true story about a little girl who lives in England. It is also an excellent starting point for a discussion of the ketogenic diet.
In the course of research into the biochemistry and physiology of the endpoints of essential fatty acid metabolism known as eicosanoids, the mechanism by which aspirin exerts its analgesic effect was revealed. It is now known that aspirin does not prevent the COX enzyme from converting arachidonic acid to pain-producing proinflammatory eicosanoids as had long been assumed, but rather it modifies the COX enzyme by acetylating it thereby making it convert arachidonic acid to antiinflammatory eicosanoids. During these same research activities, hitherto unknown classes of naturally occurring, anti-inflammatory, pro-healing eicosanoids known as lipoxins, resolvins, protectins, neuroprotectins, and maresins were discovered. Aspirin was found to multiply many times the healing power of these natural lipid mediators by creating aspirin-triggered counterparts to all.
In an earlier post, we wrote that today’s biochemistry defines disease as failure to heal. This biochemistry further shows that failure to heal is caused by the modern American diet. What is wrong with this diet? Too much sugar, starch, and vegetable fats and oils, and not enough protein, and fats and oils derived from animals and fish.
A major function of a healthy body is to continuously heal itself against almost every type of insult. Damage occurs constantly from microorganisms, cosmic rays, etc, and the body works constantly to heal itself. From my side of the world, disease is defined as failure to heal. Failure to heal in a skin wound results in a backup type of healing called scar tissue. Failure to heal in the brain causes scar tissue in the brain that experts can see during autopsy. This tissue is said to be the cause of Alzheimer’s disease.
Cover of the 1st Edition of Modern Nutritional Diseases by Frank and Alice Ottoboni
The following text is excerpted from Lipids (Chapter 8) of Modern Nutritional Diseases
, 2nd Edition.
Ketone Bodies and Ketosis: Ketones are organic chemicals in which an interior carbon in a molecule forms a double bond with an oxygen molecule. Acetone, a familiar chemical, is the smallest ketone possible. It is composed of three carbons, with the double bond to oxygen on the middle carbon. Biological ketone bodies include acetone, larger ketones, and biochemicals that can become ketones. The most important of the ketone bodies are hydroxybutyrate and acetoacetate, both of which are formed from condensation of two acetyl CoA molecules. Acetone is formed from a nonenzymatic decarboxylation of acetoacetate.