If you can’t read Cancer as a Metabolic Disease, this might be the next best thing. It’s an interview with Thomas Seyfried, in which he covers much of the material in his book (albeit at a more approachable level for the average Joe).
One of the most beautifully written and compelling parts of Seyfried’s exhaustive hypothesis is the idea that metastasis is too complex of a process to be accounted for by random genetic mutation. The idea that many different types of cancer cells would all somehow collect the right genetic mutations that would make them able to enter and exit tissues, evade detection by the immune system, and spread throughout the body seems ludicrous. From the very beginnings of Cancer as a Metabolic Disease, Seyfried begins to question this and show how the process of metastasis involves abilities already present in some macrophages and leukocytes:
I have many reasons for wanting to read this book:
- non-hodgkins lymphoma
- merkel cell carcinoma
- breast cancer
- liver cancer
- pancreatic cancer
- bladder cancer
- lung cancer
- colon cancer
- more (sadly)
I’ve only had time to thumb through it so far and, well, it’s gorgeous. Quality paper, some full color illustrations, nice binding…they certainly didn’t go cheap on this book.
So thanks again to Wiley for being so generous. I can’t wait to dig in!
Some people lust after cars, or wealth, or beautiful things. Apparently, I’m demented enough to lust after books.
But what a book…
I’ve been following Seyfried for quite a while now. His talk at Ancestral Health Symposium 2013 (AHS13) is renowned. His research, promising. And his interviews, fascinating.
Cancer As A Metabolic Disease is Seyfried’s treatise on the subject, his omnibus on the subject. In it, he builds upon the concepts first articulated by Otto Warburg (of, “The Warburg Effect” fame) and covers insights gleaned from decades of research in his own lab at Boston College.
Thomas Seyfried’s talk at Ancestral Health Symposium 2012 (AHS12) is a deep dive into the origins of cancer, loosely framed around the question, “Is cancer a metabolic disease?” In some ways an extremely provocative talk, but fascinating to watch him step through the science behind assertions like, “Regardless of what you might read, mutations are not the cause of cancer.” (Hint: it’s the mitochondria! “We never find completely normal mitochondria in any cancer cells.”)